Down syndrome (DS), also called Trisomy 21, is a combination of physical abnormalities and mental retardation characterized by a genetic defect in chromosome pair 21. Down syndrome is the most common cause of mental retardation and malformation in a newborn. It is named after John Langdon Down, the British doctor who described the syndrome back in 1866.
The cause of Down syndrome was then discovered in 1959. Down syndrome is relatively well known, with distinctive characteristics such as mental retardation, distinguishing facial features, and other traits. In the United States, Down syndrome occurs in 1 in 800 live births, and approximately 6000 children are born with Down syndrome each year. About 85% of infants with Down syndrome survive 1 year, and 50% of people with Down syndrome live longer than 50 years.